Sigma – 1 receptor (S1R) is a unique pluripotent modulator of living systems and has been reported to be associated with a number of neurological diseases including pathological pain. Intrathecal administration of S1R antagonists attenuates the pain behavior of rodents in both inflammatory and neuropathic pain models. However, the S1R localization in the spinal cord shows a selective ventral horn motor neuron distribution, suggesting the high likelihood of S1R in the dorsal root ganglion (DRG) mediating the pain relief by intrathecally administered drugs. Since primary afferents are the major component in the pain pathway, we examined the mouse and rat DRGs for the presence of the S1R. At both mRNA and protein levels, quantitative RT – PCR (qRT – PCR) and Western confirmed that the DRG contains greater S1R expression in comparison to spinal cord, cortex, or lung but less than liver. Using a custom – made highly specific antibody, we demonstrated the presence of a strong S1R immuno – fluorescence in all rat and mouse DRG neurons co – localizing with the Neuron – Specific Enolase (NSE) marker, but not in neural processes or GFAP – positive glial satellite cells. In addition, S1R was absent in afferent terminals in the skin and in the dorsal horn of the spinal cord. Using immuno – electron microscopy, we showed that S1R is detected in the nuclear envelope and endoplasmic reticulum (ER) of DRG cells. In contrast to other cells, S1R is also located directly at the plasma membrane of the DRG neurons. The presence of S1R in the nuclear envelope of all DRG neurons suggests an exciting potential role of S1R as a regulator of neuronal nuclear activities and / or gene expression, which may provide insight toward new molecular targets for modulating nociception at the level of primary afferent neurons. 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

In the article it had analyzed the condition of the coat of lambs differing in terms of embryonic development. The study was conducted in the farm engaged in karakul sheep cultivation and laboratories of the SZSRIZP institute. The results of comparative analysis of lambs from different groups show a low level of their differences. The fiber wool of karakul lambs in natural conditions are kept from dryness, the silkiness of the wool increases the quality of the skin. A sufficient degree of silkiness provides rainproofness through the body of the lambs. Reporting of the productive qualities of the young, including the definition of morphological indicators of the lamb's wool cover was carried out according to the "Tribal recommendation of the Karakol sheep". At the stage of embryonic development, the Karakol lambs depend on the influence of the morphological composition of the unevenness of the coat of wool and the length of the fiber. Wool is used in farms engaged in the cultivation of karakul sheep.

The main goal of the work – in the laboratory conditions of re – infected guinea pigs with atypical microbacteria sensibilous and virulent strains – to determine from pathological materials tuberculosis antigens a point immune enzymatic assay determination by direct formulation.
Recharged guinea pigs atypical ivirulenovymi microbacteria during the work used pathological materials. Recharged guinea pigs after 3 months are killed and opened, examine the pathomorphological changes, and discussed the analysis.
From the pathological material of guinea pigs (liver, pieces of lung, lymph glands, urine) for the determination of tuberculosis antigens with points of the IFT – results, the pathomorphological changes were evaluated on the basis of comparison.
As a result, M. Bovis strains 8 were obtained from recharged guinea pigs, the pathological materials of all the invading antigens were obtained as a result of the analysis, and in the urine test only the first showed a positive result. From re – infected animals in the laboratory, atypical microbacteria and M. tuberculosis, all samples obtained gave negative results. Pay attention to the pathological changes, all recharged by microbacteria in the body in guinea pigs, changes were observed. Pointed IFT – a results of pathological study only in the form of Mycobacterium bowis corresponding to the results of the determination, the study of a point – like IFT – a has been proved. A sample of tuberculosis antigens is studied by the conjugate by the interaction of sensitivity in the lymph nodes 1: 8 – 1: 16, in the lungs 1:64 – 1: 128, in the liver 1: 32 – 1.64 if between titres, then in urine this figure is 1:16 titer.
In the lungs and liver, the antigens of tuberculosis studied by the conjugate as a result of the interaction showed high sensitivity. Peroxidase – labeled labeled monoclonal antibodies are developed mainly by point – like immune enzymatic analysis of antigens of pathological materials of tuberculosis can be determined by direct formulation.

In the recent time, there is a tendency of scientific interest in goat milk, as the main raw material, for the production of functional products. More and more applications in recent years, products based on goat milk, possess valuable nutritional properties for human life. It is known that milk of goats more correspond to the physiological characteristics of the human body than cow's. The article presents the results of research of technological and physico – chemical properties of goat milk of different breeds for the production of soft cheese varieties. A comparative analysis of milk of different breeds goats has been carried out, as well as the composition and properties of cheese whey. The prieferential characteristics of milk and whey of native breed of goats of Pavlodar region in comparison with goats of Zaanen and Alpine breed are revealed.

The article examines the geoecological assessment of the state of the territory of the North Kazakhstan region using the example of the Ualikhanovsky district. The main land use problems are identified, which lead to a decrease in soil fertility. The favorable situation of the administrative regions of North Kazakhstan and the prerequisites for further balanced land use is assessed. Regional geoecological analysis is aimed at preventing, reducing or eliminating the adverse effects of anthropogenic (technogenic) impact on natural and territorial complexes (landscapes), economic and social conditions of human activities in specific regions. The diverse landscapes of the steppe and steep zones possessing high ecological potential have long been involved in the economic activities of the person: at the present stage they develop under conditions of high anthropogenic pressures. Geoecological analysis is used as a system of observations of sources and factors of anthropogenic impact on land resources with a view to timely detecting their changes, as well as estimates and pr – gnoza consequences of negative processes. The region is dominated by modified and transformed PTC, in its structure and features of functioning very different from the natural ones. In such conditions, deep all – sided eco – diagnostics becomes the basis for forecasting the landscape – ecological status of the region and managing nature management. It has been revealed that, for the optimization and sustainable development of landscapes in the North Kazakhstan region, partial estsnification of agricultural land use is necessary, expressing in selective transfer a plant from low – yielding arable land to pastures, which will lead to stabilization of the ecological status of the natural territorial complex of the region.

One of the important tasks of public health is the creation of highly effective medicines and the provision of medical needs. In this connection, it becomes necessary to search for the most promising medicinal plants, to select species from the natural flora, populations that have a high potential for the synthesis of biologically active substances. This work is devoted to the study of the chemical composition of biologically active wood processing compounds of willow family, namely, aspen and poplar bark, as a promising raw material for use in medicine and the production of herbal medicines. Preparations from vegetable raw materials in comparison with synthetic medicines have a number of advantages. They are low – toxic and rarely have a side effect. Being complex in composition, they contain many ingredients that give them valuable properties and provide a multilateral effect on the body, stronger than the action of each of them individually. In this paper, we qualitatively determined the lipid composition, phenolic acids, flavonoids, carbohydrates, amino acids, as biologically active compounds, by means of which the presumed medicinal raw material has an important medicinal value. Investigation of the chemical composition of biologically active compounds in the poplar and aspen bark was carried out by thin – layer chromatography on "Silufol" plates and by paper chromatography. In the course of the work, we proved that the qualitative composition of the bark of aspen and poplar does not differ from each other. They contain a rich complex of biologically active substances: lipids, phenolic acids, flavonoids, carbohydrates, amino acids. Therefore, these plants can be recommended to use as a medicinal raw material for making phytopreparations.

The results of scientific and economic experience on the fattening of young horses are presented with the use of green mass of rapeseed and oats of late sowing periods. The green mass of these crops was fed by foraging and fattening on the site. To determine the efficiency of autumn feeding in late summer crops of spring rape and oats and subsequent short – term fattening using green mass of rapeseed and oats, scientific and economic experience was conducted at ABI – ZHER LLP. The farm does not have enough natural pastures for horses to graze, in connection with this, crops of late – summer frost – resistant crops were planted as rape and oats for the autumn – winter grazing of horses. Before intensive short – term fattening, previously in the foraging, it is necessary to bring the animals to a good average fatness. Since, if immediately put young animals for copious feeding there is a strong deposition of fat with a weak build – up of muscles, the carcass of such animals is produced with an excess of subcutaneous and internal fat, and meat – of low quality. When feeding, combined with intensive fattening, meat production increases, its quality improves, the sales value increases and costs per unit of production decrease.
For the short – term fattening of the individual livestock premises, 23 single fattening cells were used to organize individual fattening of horses, as well as 6 group cages, for keeping young and fattening horses. In the beginning after feeding, the animals are in group cages then transferred to individual cells for final fattening. The results of the conducted studies show that the technology of short – term fattening combined with feeding, the use of green mass of rapeseed and oats in feedlot rations had a definite effect on the dynamics of live weight and the average daily growth in animals. The effectiveness of this method is due to an additional increase in live weight and an improvement in slaughter indicators.

Since the 80 s of the last century there has been a clear trend towards the expansion of black – winged stilt areal in the South of Western Siberia, as evidenced by numerous publications. In Western Europe nesting of black – winged stilt had been noted even earlier.
The steppe lakes of Northern Kazakhstan are characterized by such a phenomenon as the pulsation of the areal of many wetland birds, when the boundaries of the areal can expand and narrow down to hundreds of kilometers. This is closely related to the periodic abundant watering and shallowing of lakes in Western Siberia, as indicated by many authors. Since the 80s of the twentieth century, attention has been drawn to the appearance of the black – winged stilt (Himantopus himantopus) in the vicinity of Petropavlovsk – a bird of the tropics and subtropics that is not specific to our area. During the years of observation, the nesting biology and phenology of the arrival and departure of this species have been studied, the causes of embryonic and postembryonic mortality of the stilt have been found out.
In recent years, bird colonies in the vicinity of Petropavlovsk have ceased to form and the reason for this is not the natural pulsation of the area. At the beginning of the third Millennium, after some decline in the agricultural sector of the economy, the rise of agricultural production in Northern Kazakhstan is again observed, the former areas of arable land are being restored, and the number of livestock is growing.
One of the main reasons underlying various manifestations of human activity was the growth of the population on the developed lands, withdrawal of natural lands for industrial and civil construction. In the current situation, the identification of the main causes and patterns of changes in the number of water birds, the distribution patterns of the various types of water bodies, the reproductive potential and the factors that determine it, would later allow rational planning of measures to conserve the number and biodiversity of water and wetland birds.
The true reasons for disappearance of colonies of waders, including stilts, in the suburbs of Petropavlovsk are discussed in this article.

The article presents some issues on the application of OECD standards (Organization for Economic Cooperation and Development, France, Paris) within the framework of scientific and technological development of the agro – industrial complex in the Republic of Kazakhstan. Particular emphasis is placed on the recommendations of the President of the country N. Nazarbayev on the need to introduce and further apply the OECD standards in Kazakhstan. Various points of view of modern domestic researchers are presented with regard to the innovative development of the agro – industrial complex in the country. The statistical information reflecting the current state of the scientific and technological sphere of the Republic of Kazakhstan is analyzed. At the same time, special attention is paid to indicators characterizing the innovative development of the country's agricultural sector. Among them, GDP, intramural research and development (R&D) expenditures, the ratio of the level of intramural R&D expenditures to GDP. In conclusion, author's recommendations are given, the implementation of which will increase the innovative potential of the agro – industrial complex of the Republic of Kazakhstan.

This article discusses the role and importance of historical science, the need to study it, as well as the Humanities and worldview in General. About the increased interest in the Republic of Kazakhstan, in particular, in the scientific world, to its own national history.
The author highlights the issues of changing the thinking of Kazakhstanis, their worldview and attitude with promising results in behavioral motivation, qualitative changes in the results in the field of economy and social development of society, revealed in the works of the Head of state: the program article «Look into the future: modernization of public consciousness», in the work «In the flow of history», in the book «Era of independence».
Particular attention is paid to the desire to study the role of the national movement «Alash» in the revival of the statehood of Kazakhstan, strengthening the national consciousness of the Kazakhs, the development of the foundations of tolerance and friendship of the people of the great steppe. Mapped the most important problems of modern moral – philosophical definitions, allocated by the President of the Republic of Kazakhstan N.А. Nazarbayev and the ideological program of the party «Alash». Three issues are considered within the framework of the public theme: «Alash» in the history of statehood of Kazakhstan: ideas, destinies, heritage (in the context of spiritual modernization of society): «Alash» and modernization of public consciousness; the ideal heritage of the «Alash" party and the formation of the foundations of civil identity in the Kazakh society; tasks of school and higher education for the education of modern Kazakhstan as a citizen and patriot.

It is presented in article that development of small business has some difficulties which are caused by the fact that the contingent occupied in this sphere, as a rule, has no necessary economic and legal knowledge without which carrying out serious market researches, adoption of reasonable decisions on the problems connected with sale of goods and services and also elaboration of effective strategy and tactics for conducting competition with the large companies is impossible. On the basis of a complex research of the small and medium business functioning on the basis of the franchasing relations, franchizing is defined as a special form of the business environment organization which allows firm to support and create the dominant positions in the market. Franchizing provides to small firms a certain set of the services directed to maintenance of the leading positions in the market of a concrete product.
The existing problems in the market of franchizing of the Republic of Kazakhstan are also defined. The main problems which had by subjects of small business are financial difficulties and also deficiency of the qualified labor capable to carry out administrative, legal, marketing and consulting functions.
The responsible role to the state in development of franchizing in Kazakhstan is defined. The events directed to support of development of small business which are held by the Government of RK and also local executive bodies and the other organizations are designated.
On the basis of the analysis authors have developed model for development of the market of franchizing in the Republic of Kazakhstan which contains the concrete directions of development, an action and the responsible parties of development and also a measure for elimination of problems. For functioning of model of development of franchizing conditions which are created by one subjects of the franchasing relations, but in turn, increasing their welfare and exerting impact on others are recommended. The developed model will allow to create qualitative state programs on business support, having avoided inexpedient expenditure of means of the state budget

It is presented in article that development of small business has some difficulties which are caused by the fact that the contingent occupied in this sphere, as a rule, has no necessary economic and legal knowledge without which carrying out serious market researches, adoption of reasonable decisions on the problems connected with sale of goods and services and also elaboration of effective strategy and tactics for conducting competition with the large companies is impossible. On the basis of a complex research of the small and medium business functioning on the basis of the franchasing relations, franchizing is defined as a special form of the business environment organization which allows firm to support and create the dominant positions in the market. Franchizing provides to small firms a certain set of the services directed to maintenance of the leading positions in the market of a concrete product.
The existing problems in the market of franchizing of the Republic of Kazakhstan are also defined. The main problems which had by subjects of small business are financial difficulties and also deficiency of the qualified labor capable to carry out administrative, legal, marketing and consulting functions.
The responsible role to the state in development of franchizing in Kazakhstan is defined. The events directed to support of development of small business which are held by the Government of RK and also local executive bodies and the other organizations are designated.
On the basis of the analysis authors have developed model for development of the market of franchizing in the Republic of Kazakhstan which contains the concrete directions of development, an action and the responsible parties of development and also a measure for elimination of problems. For functioning of model of development of franchizing conditions which are created by one subjects of the franchasing relations, but in turn, increasing their welfare and exerting impact on others are recommended. The developed model will allow to create qualitative state programs on business support, having avoided inexpedient expenditure of means of the state budget

Use of applied art at English lessons became one of popular techniques in modern teaching. It allows to make the atmosphere of creativity and the communication based on this creativity where the creative thought is primary and exists in images, but not in a verbal form of the native language that does communication torn more off from thinking in the native language, more figurative.As process of the speech interaction itself includes use, both language, and grammatical structures, therefore creation of the direct communicative environment in the learned language is the best way to achieve the required objectives through interaction of pupils with each other and also with their teacher. The known information forms students’ base for the discovery of something unknown through evident materials which help them to master new words and structures. Explanations are offered by the teacher only when the help is necessary and excluded when the pupil has to use the observation better than anything else. Art in this case is one of the most excellent means for reconciliation of pupils since helps to create the special atmosphere allowing to estimate participation of all in the course of studying of language. It is impossible to find other kind of activity which equally would rally all pupils, as during creation of exclusively unique creations in a format of art or literature to share it with the class in the learned language.

The article examines the means of depicting the image of a woman in the historical novels. For this purpose, the author relies on Gabit Musrepov’s and Zadan Zhumagali’s opinions emphasized the importance of various expressive means contributing to making an women’s image describing personal qualities.
In I. Esenberlin’s trilogy «Koshpendiler» the author’s artistic skill is manifested through the images of Zhagan bike, Akkozy, Kunimzhan, and the princess Rabiga – Sultan Begim. Special attention is paid to the depiction of the artistic image of historical heroines. Through the images of the women the author depicts not only their daily life but also the actions taken by them in the most crucial moments characterizing the social, historical and political essence of the epoch.
For the better description of personal traits of the female characters the author uses monologues and dialogues more expressively and skillfully in the novel Koshpendiler.

The article discusses gaming technologies at the lessons of "Kazakh language" and "Professional Kazakh language" as one of the innovative teaching technologies, forms of conducting, effective methods of conducting, organizing situational assignments for free communicative relations, which increases the interest of learners in learning the language. Also, the Concepts on the language of the Republic of Kazakhstan are reviewed. The article points out the effectiveness and effectiveness of business and role – playing games as one of the ways of adapting the training of future professions. In the process of entering into situational activities, students are formed skills in the proper use of speech, professional terms. In his article it is written that the basis of role – playing games is communicative technologies. The author reviews all the stages of the game and gives a definition to them. The author claims that the use of gaming technology in the classroom positively affects the solution of methodological problems.

Industry is the most important branch of the national economy, which has a decisive impact on the level of development of the productive forces of society. Industry structure – composition and share ratio of various industries and types of production included in it, as well as the dynamics of changes in these shares.
This article examines the economic nature and factors of industrial development in the region. The attention is focused on the fact that the factors affecting the location of the enterprise also affect the development of the economy as a whole. Such factors as technical, technological, social, legal, economic, investment, innovation, Finance.
The purpose of the policy of the industrial enterprise is to preserve the basic products of the enterprise and the development of new technologies.
The model of the regional industry development structure is presented. Development of industry in the region and the identified factors affecting it. A feature of the implementation of the program of development of industry in the region. The place and importance of industry in the South Kazakhstan region at the National level and the state of the industry. Analysis of the comprehensive development of industry and industry of South Kazakhstan region.
Special methods of theoretical analysis (system – structural, comparative – legal), basic methods of logical cognition (analysis, synthesis, generalization), historical, sociological, theoretical and experimental were used in the process of analysis.

This article deals with the problems of protection of the rights and legitimate interests of consumers in the Republic of Kazakhstan. The article uses the data of sociological and analytical research conducted by the Committee on regulation of natural monopolies, protection of competition and consumer rights of the Ministry of national economy of the Republic of Kazakhstan in 2017. It should be noted that this study has been conducted for the past three years. Sociological research is conducted in all 16 regions of the Republic of Kazakhstan. And that is typical of the results of the study changed slightly. This suggests that at the state level, the situation has not changed much. Although there are some changes: the state is trying to liberalize business, prohibits unjustified inspections, reduces taxes, cancels licensing, initiates other measures to stimulate business development. Special methods of theoretical analysis (system – structural, comparative – legal), basic methods of logical cognition (analysis, synthesis, generalization), historical, sociological, theoretical and experimental were used in the process of analysis. Sociological methods were also used, which are offered in the form of a questionnaire as an additional method to clarify some of the data analyzed in the study. Analyzed the effectiveness of legal acts in the sphere of protection of consumer rights (including the Constitution of RK, Law of RK «On protection of consumer rights»), considered the complaints of citizens to the court. The level of awareness of the population of the Republic on the protection of their rights in the study area. An attempt is made to determine the level of development of public associations for the protection of consumer rights. On the basis of the conducted research the author formulates the main conclusions on the issues of consumer protection in Kazakhstan.

The article focuses on the fact that entrepreneurship is the main driving force for the development of economic processes in society. But this factor is not developing fast enough. In the Republic of Kazakhstan, the legislative base of entrepreneurship is mainly formed, state support is provided, as indicated by the positive dynamics of the world rating indicators. This process needs to be given a more dynamic impetus and universities can play a major role.
The main reasons hindering the development of the University business environment are noted. Universities are generators of knowledge and translating them into the learning environment, not actively involved in the process of adapting them in the business environment.
The author of this article provides an overview of the interpretations of the concept of «University of entrepreneurial type». Attention is focused on a qualitatively new definition of the term «entrepreneurship». To combine these areas is called «triple helix» Henry Itzkovich. It implies a parallel interaction of universities, the state and business structures in the development of entrepreneurship. The main direction may be the creation of entrepreneurial – type universities.
The history of the recent past indicates the prospects of this direction on the example of previously operating scientific and production associations (NGOs). This research and production cluster can be formed at NKSU, on the basis of the recently established agricultural faculty. Its efficiency is determined not only as an element of the business environment, but also as a basis for training in a number of agricultural, pedagogical and engineering specialties.
The scientific, educational and organizational functions of «universities of entrepreneurial type» as a promising direction for further improvement of higher education institutions are defined. Further integration of business structures and educational institutions is needed.

This article is considered the directions of young people aesthetic development in today’s social and cultural situation. In modern society, it is considered that young people have no interest to genuine spiritual values, although in reality the tastes of young people are not lower than that of their parents and artistic interests are much more diverse. Modern youth has diverse tastes and different aesthetic preferences for attitudes toward art. From year to year we see that the changes in aesthetic interests are growing: young people have a craving for «complex cinema» and for serious art, full of relevance, civic sound, problematic and social meaning.
The actuality is in the fact that art is consonant with time and helps to understand modernity better. Art is one of the most important means of cognition. It gives us knowledge of the real connections of the world and man which can convey the entire wealth of life and express the beauty and strength of the human spirit. Boys and girls choose spiritual mentors in art for themselves, they also understand who teach them and the main is what.
But still, the following contradictions are observed in society: a high level of aesthetic consumption is getting along with a low level of social returns, clearly overstated demands to others – with very low requirements to own person, a desire for aesthetic self – expression – with indiscriminate aesthetic means that is why the necessity in some aspects of young people aesthetic development considering is appeared.

Wearable computing places tighter constraints on architecture design than traditional mobile computing. The real structure of the computer is much more complicated than the structure of mobile computers. In modern computers, in particular personal computers, there is increasingly a departure from the traditional architecture of von Neumann, due to the desire of developers and users to improve the quality and performance of computers. The quality of a computer is characterized by many indicators. This is a set of commands that the computer is able to understand, and the speed of the CPU, the number of peripheral I / O devices connected to the computer at the same time. The main indicator is the speed – the number of operations that a processor can perform per unit of time. In practice, the user is more interested in the performance of the computer – the indicator of its effective speed, that is, the ability to not just quickly function, but quickly solve specific tasks.The architecture is described in terms of miniaturization, power – awareness, global low – power design and suitability for an application. A system – in – a – package (SiP) generally contains a variety of systems such as analog, digital, high frequency and micro electro mechanical systems, integrated in a system – level package connected through a substrate. In this article we propose a SiP model and the packaging implementation of the SiP as a complete microsystem.

The work presents scientific research about influence of automation of welding process on the welding connection quality. General questions of providing of welding connection quality, work principals of automatic control systems of welding process are examined in this article. Also attention is paid to the methods of realization of quality control and research of basic parameters of welding joints. In the article the examples of work of automatic close systems of welding process are given. The aim of welding processes automatization is the quality of weld seams at the highest economic indicators with minimal human participation. Systems of automated control with the usage of computers and microcontrollers with the automatic welders allow reducing part of hand labor in welding process and to improve efficiency and quality of weld seams. Certification influences not just on the quality of weld seams but also on the products increasing their durability that influences on savings. That’s why creation of effective and at the same time utility systems of automated control for weld seams formation nowadays is of scientific and practical interest.

The work is a scientific study of the evaluation of the effectiveness of the use of automated dispatch control systems in housing and communal services. In this paper, topical issues of the principles of the operation of dispatcher services with the use of automated control systems are considered. The work gives examples of the work of automatic dispatching services, specifies the main aspects of assessing the effectiveness of such a system in large industrial enterprises. The methods of object – oriented analysis are used in the work to plan and implement the modernization process of the information system. The subject of the study is an automated control system. The object of the study are automated control systems used in the service sector. The author outlines the basic information on the use, operation and organization of the development of automated control systems, their subsystems, databases, automated workplaces in relation to the urban housing and communal services. Particular attention is paid to the basic characteristics of systems for automated identification of objects and communication systems. Solutions are given to increase the efficiency of work with information resources of enterprises in the planning and monitoring process. The novelty of the research is to apply a systematic approach to the design of an information system and to consider not only technological but also economic factors. The methods of optimization of production processes with the use of corporate automated dispatch control systems are investigated. Work in the present time is relevant and in demand.

Ensuring the sustainable development of human society is impossible without a stable state of the natural environment. Water is a necessary part of the environment of existence, and has a significant impact on human health. This is especially true of the part that is a drinking water supply. In recent years, there has been a decline in the quality of water in surface water supply sources, which increases the problem of clean drinking water. In this paper, the main issues of the impact of an effective assessment on the quality of water consumed by people  are examined. Actual issues considered in this article are the environmental problems of the North Kazakhstan region. Examples are given and methods of assessment, as well as methods for conducting statistical studies on water quality assessment. To date, the work is relevant and covers various areas of science.

The article is devoted to the modern concepts issue of personal development, the problem of rethinking value orientations of educational theories, ways of mastering the national heritage, naturally introducing a child to the basics of traditional folk culture, which will contribute to the development of a tolerant, multicultural personality.
Polycultural education as an important part of modern general education, aimed at interethnic integration and contributing to the understanding of the general and the special (unique) in the traditions, lifestyle, cultural values of a number of living nations, education of young people in the spirit of mutual respect.
Each human individual acts simultaneously in two ways: he perceives himself to be a representative of the human race and, at the same time, as a member of a certain ethnic group, a nation. As a representative of the human race, as a person, the individual acts as a carrier of universal human values. Education for tolerance at the primary level of education in the student development and teacher; level implies the development of tolerance towards cultural differences among schoolchildren.

The article is devoted to multicultural educational fieldin English classes. The prerequisites for the development of the multicultural educational space are specified in this issue. The priority task of school is examined in the conditions of multicultural educational space. The results of theoretical researches are presented in the field of multicultural educational space. Special attention is paid to the dialogue approach in education. Results emphasize the main indicators of success multicultural educational space. The successful personality integration into the national and world culture is considered from a position of inclusion in the multicultural educational field. Multicultural educational field is considered as a set of educational systems, within its limit a certain place is assigned, is organized in the way of state system. The main idea of multicultural education filed in English classes is to equip students with the relevant knowledge, to form and develop skills allowing them to actively and productively interact with representatives of different cultures, the primary task of multicultural education is to foster respect for cultural differences and to prepare students for a real life in multicultural educational space. At present, ideas of multicultural educational field penetrate into educational institutions intensively. Through multicultural education, it is proposed to encourage the desire of schoolchildren to acquire knowledge, skills, develop the abilities.

The images of historical stage and the artist`s skill is one of the topical problems of Kazakhstan art history. The article reveals the features of paintings depicting the historical events of the country. And also the artist`s skill in drawing up composition, content and color of the picture is determined. Definition of the artist's skill level is revealed by the critic's critical relationship with the artist's work in drawing up an iconic historical scene. One of the criteria for determining the artist`s skill is an art – historical formation that is necessary in the process of drawing up the composition about the historical past of the country. An art criticism analysis in two directions: first, artistic analysis of historical paintings that makes up the structure in terms of the painting idea, the painting coloring, composition and performance techniques; second, the activity analysis of Kazakhstan artists in the reality structure of historical scene and decision transmission is revealed in the article. In addition, the semantic content of the concept as «master's work», «skill», «artistic image», «image of the era», «image of history» is defined in the article.

The article is devoted to the issue of research of the development of tolerance, which will promote the development of tolerant attitude towards people with disabilities. In the recent years"tolerance" has become not only a common and international term, but also one of the most urgent topics of modern humanities, including psychology. In the context of problems related to interpersonal and intergroup relations, tolerance is developed in social psychology. A tolerant attitude toward another person requires recognition and understanding that the person is not just another, but also has the right to be different.
The article is devoted to the issue of research of the development of tolerance, which will promote the development of tolerant attitude towards people with disabilities. In recent years, «tolerance» has become not only a common, international term, but also one of the most urgent topics of modern humanities, including psychology. Tolerance is developed in social psychology in the context of challenges posed by interpersonal and inter – group relations. A tolerant attitude toward another person requires recognition and understanding that the person is not just another, but also has the right to be different.

In the article, the concepts «motivation», «motivational process» are considered, methods of methodical recommendations. Considers are necessary to take into account the nature of tasks in terms of complexity and to summative pricing. Ways to intensify students, interest in the formation of educational materials, formulate problem situations, various methods of cognitive activity management, focusing on activating thinking, providing mutual assistance, implementing student cooperation in small and medium – sized groups school subjects, building the ability to properly organize relationships with other students. The need for the teacher to be interested in the success of his students, see the individuality of each student, to motivate him cognitive activity in order to develop critical and divergent thinking, not only in the teaching process, but also his further career. Considers such an actual topic for today as the topic of psycho – programming of needs, which explorers motives of behavior. Here the question is posed: is it possible to formulate such questions, to what extent is it moral, and what will this bring to mankind.

In the modern world, one of the main tasks of the education system is the development of creativity. Creativity – (persistent. create – to create, creative – creative, creative) – creative abilities characterized by readiness to create fundamentally new ideas that deviate from traditional or accepted patterns of thinking, and included in the structure of giftedness as an independent factor, as well as the ability to solve problems arising within static systems. Creativity has many advantages. Creativity allows you to solve tasks, a good idea can help you find a way out of a difficult situation. Creative thinking helps a person to find the most unusual ways of development. Creativity makes life infinitely diverse. Creativity allows you to realize a creative idea. Creativity helps to find ways for self – realization.
The article discusses the development of creative thinking of students in the process of implementing degree works. The importance of development of creative thinking is shown. Described methods that can be used in the development of the methodology for the students` creative thinking development in the process of implementing degree works. The work to date is relevant.