OXIDATIVE MODIFICATIONS OF BETULIN

Triterpene compounds, in particular triterpene alcohol betulin, have high biological activity along with low toxicity. Betulin is easily and with a large yield extracted from birch bark, which makes it promising in terms of use in medicine. It has been established that oxidized betulin derivatives have anti– cancer and antiviral activity. However, recent studies on the preparation of oxidized betulin derivatives are distinguished either by low conversion of the substance or by the difficulty of extracting individual substances. This study is devoted to the creation of betulin oxidation techniques with a high conversion of the substance and ease of purification of the obtained oxidized betulin derivatives. This method of obtaining oxidized betulin derivatives allows to achieve a high conversion of the substance and at the same time is notable for the ease of purification of the obtained oxidized betulin derivatives. The high biological activity of the obtained oxidized compounds using the proposed technique, as well as the cheapness of the synthesis and raw materials, will make it possible to consider them as promising substances for use in medical chemistry.

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