Meta-analysis of dna repair gene polymorphism in population living in areas with high radon levels

Lung cancer is one of the most common oncological diseases in the world. The World Health Organization identifies radon as the second most important risk factor for the development of this malignant neoplasm after smoking. The study of DNA repair gene polymorphisms plays a key role in uncovering the mechanisms of radon-induced carcinogenesis.

The aim of this study was to assess whether OGG1 (rs1052133), ERCC1 (rs13181, rs11615, rs3212986), XRCC1 (rs25487), and XRCC3 (rs861539) gene polymorphisms are associated with the risk of radon-induced lung cancer.

As part of the work, a meta-analysis was conducted to study the associations between these genetic polymorphisms and the likelihood of radon-induced lung cancer. Four studies, covering 1,648 patients with radon-induced lung cancer and 1,750 controls, were included in this meta-analysis. The results of the meta-analysis showed no significant association between the development of radon-induced lung cancer and the following polymorphisms: ERCC2 (rs13181), ERCC1 (rs11615), XRCC1 (rs25487).

Statistically significant associations were found for the following genetic polymorphisms: OGG1 (rs1052133) in additive and dominant models; ERCC1 (rs3212986) in a recessive model; XRCC3 (rs861539) in recessive and dominant models. These results indicate a possible association of OGG1 (rs1052133), ERCC1 (rs3212986) and XRCC3 (rs861539) polymorphisms with predisposition to radon-induced lung cancer.

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