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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">koz</journal-id><journal-title-group><journal-title xml:lang="ru">"Вестник Северо-Казахстанского университета имени Манаша Козыбаева"</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Manash Kozybayev North Kazakhstan University</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2958-003X</issn><issn pub-type="epub">2958-0048</issn><publisher><publisher-name>М. Қозыбаев атындағы СҚУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.54596/2958-0048-2024-2-48-53</article-id><article-id custom-type="elpub" pub-id-type="custom">koz-1517</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БИОЛОГИЧЕСКИЕ НАУКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BIOLOGICAL SCIENCES</subject></subj-group></article-categories><title-group><article-title>ПРОТИВОВОСПАЛИТЕЛЬНАЯ АКТИВНОСТЬ ЭКСТРАКТОВ ЛИСТЬЕВ PLANTAGO MAJOR IN VITRO НА ЭПИТЕЛИАЛЬНЫЕ КЛЕТКИ ПОЛОСТИ РТА</article-title><trans-title-group xml:lang="en"><trans-title>ANTI-INFLAMMATORY ACTIVITY OF PLANTAGO MAJOR LEAF EXTRACTS IN VITRO ON EPITHELIAL CELLS OF THE ORAL CAVITY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4878-4030</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Атибаева</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Atibayeva</surname><given-names>А. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Астана</p></bio><bio xml:lang="en"><p>Astana</p></bio><email xlink:type="simple">mr.tynykulov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тыныкулов</surname><given-names>М. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Tynykulov</surname><given-names>M. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Астана</p></bio><bio xml:lang="en"><p>Astana</p></bio><email xlink:type="simple">mr.tynykulov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НАО «Евразийский национальный университет им. Л.Н. Гумилева»<country>Казахстан</country></aff><aff xml:lang="en">NCJSC «L.N. Gumilyov Eurasian national university»<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>29</day><month>05</month><year>2024</year></pub-date><volume>0</volume><issue>2 (62)</issue><fpage>48</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Атибаева А.Е., Тыныкулов М.К., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Атибаева А.Е., Тыныкулов М.К.</copyright-holder><copyright-holder xml:lang="en">Atibayeva А.E., Tynykulov M.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.ku.edu.kz/jour/article/view/1517">https://vestnik.ku.edu.kz/jour/article/view/1517</self-uri><abstract><p>Большой подорожник с древних времен широко использовался для лечения многих заболеваний, включая запоры, кашель и язвы. Целью этого исследования является обзор традиционного использования, ботанических характеристик, фармакологической активности, фитохимических эффектов и токсичности Plantago major. Некоторые из его традиционных свойств, включая ранозаживляющее, жаропонижающее, противокашлевое, противоинфекционное, против геморрагическое, противовоспалительное, мочегонное, слабительное, вяжущее и кровоостанавливающее, были подтверждены недавними исследованиями. Фитохимические исследования показали, что Plantago major содержит летучие соединения, тритерпеноиды, фенольные кислоты и флавоноиды. Текущие фармакологические исследования доказали некоторые традиционные применения Plantago major. Однако необходимы дополнительные исследования этого растения, поскольку его можно использовать для производства различных природных препаратов. Целебные свойства большого подорожника были признаны во всем мире на протяжении сотен лет.Это растение содержит ряд эффективных химических компонентов, таких как флавоноиды, алкалоиды, терпеноиды, производные фенольной кислоты, иридоидные гликозиды, жирные кислоты, полисахариды и витамины, которые способствуют его специфическому лечебному эффекту. Соответственно, исследования показали, что большой подорожник эффективен как ранозаживляющее средство, а также как противораковое, противодиабетическое, противодиарейное, противовоспалительное, антиноцицептивное, антибактериальное и противовирусное средство. Он также борется с усталостью и раком, является антиоксидантом и нейтрализует свободные радикалы.</p></abstract><trans-abstract xml:lang="en"><p>The large plantain has been widely used since ancient times to treat many diseases, including constipation, cough and ulcers. The purpose of this study is to review the traditional use, botanical characteristics, pharmacological activity, phytochemical effects and toxicity of Plantago major. Some o f its traditional properties, including wound healing, antipyretic, antitussive, anti-infective, anti-hemorrhagic, anti-inflammatory, diuretic, laxative, astringent and hemostatic, have been confirmed by recent studies. Phytochemical studies have shown that Plantago major contains volatile compounds, triterpenoids, phenolic acids and flavonoids. Current pharmacological studies have proven some of the traditional uses of Plantago major. However, additional studies of this plant are needed, since it can be used for the production of various natural preparations.The healing properties of the great plantain have been recognized all over the world for hundreds of years. This plant contains a number of effective chemical components, such as flavonoids, alkaloids, terpenoids, phenolic acid derivatives, iridoid glycosides, fatty acids, polysaccharides and vitamins, which contribute to its specific therapeutic effect. Accordingly, studies have shown that the large plantain is effective as a wound healing agent, as well as as an anti-cancer, antidiabetic, antidiarrheal, anti-inflammatory, antinociceptive, antibacterial and antiviral agent. It also fights fatigue and cancer, is an antioxidant and neutralizes free radicals.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>подорожник большой</kwd><kwd>лекарственные растения</kwd><kwd>Plantago major</kwd><kwd>экстракт</kwd><kwd>воспаление</kwd><kwd>in vitro</kwd></kwd-group><kwd-group xml:lang="en"><kwd>plantain large</kwd><kwd>medicinal plants</kwd><kwd>Plantago major</kwd><kwd>extract</kwd><kwd>inflammation</kwd><kwd>in vitro</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Powis G. Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man. Drug metabolism reviews 1983: 14(6): 1145-1163.</mixed-citation><mixed-citation xml:lang="en">Powis G. Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man. 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